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Cortical neuron apoptosis after mechanical subcortical transection in rats

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Author:
No author available
Journal Title:
JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
Issue:
19
DOI:
10.3321/j.issn:1000-2790.2004.19.003
Key Word:
脑损伤;皮层下横切;细胞凋亡

Abstract: 目的:探讨在机械性脑白质损伤后皮层神经元凋亡及其分布特征.方法:制作大脑皮层下横切动物模型,于致伤后不同时间处死动物,用TUNEL原位末端标记和病理组织学方法观察损伤区及相应皮层神经元变化规律.结果:致伤后,损伤部神经元出现坏死,胶质细胞增多,大脑Ⅱ~V层神经元多出现萎缩.伤后12 h,相应皮层内即出现散在凋亡神经元,后渐增多,7 d后又趋减少,伤后19 d皮层内仍可检出凋亡神经元,而在损伤区凋亡神经元少见,其时间分布呈一单峰状曲线.结论:脑白质损害时,损伤相应部位皮层神经元主要表现为凋亡,分布于第Ⅱ~V层.

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