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Effects of U50488H on ventricular arrhythmias induced by myocardial ischemia and reperfusion in rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 18
- DOI:
- 10.3321/j.issn:1000-2790.2004.18.005
- Key Word:
- U50488H;受体,阿片样,к;心肌再灌注;心律失常
Abstract： 目的: 研究选择性к阿片受体激动剂U50488H对大鼠心肌缺血再灌注室性心律失常的影响. 方法: 将实验大鼠按随机原则分为4组,即对照组(Control)、缺血再灌注组(Ⅰ/R)、U50488H组和U50488H+Ⅰ/R组,监测大鼠心率(HR)、动脉压(ABP)、左心室内压(LVP)及收缩(+dp/dtmax)和舒张功能(-dp/dtmax)等血流动力学指标,并观察室性心律失常的发生情况. 结果: ① U50488H可显著降低大鼠HR,ABP,LVP及±dp/dtmax;②在心肌缺血前预先给予U50488H,可明显降低大鼠心肌缺血再灌注室性心律失常的发生率以及室性心律失常评分,该作用可被选择性к阿片受体阻断剂Nor-BNI阻断. 结论: U50488H可改变心脏节律,并通过激动心脏к阿片受体减少大鼠心肌缺血再灌注室性心律失常的发生.
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