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Serotoninergic projections from periaqueductal gray and dorsal raphe nucleus to parabrachial nucleus in rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 16
- DOI:
- 10.3321/j.issn:1000-2790.2004.16.001
- Key Word:
- 血清素;水管周灰质;中缝核;臂旁核;大鼠
Abstract： 目的: 观察大鼠中脑导水管周围灰质(PAG)和中缝背核(DR)内的5-羟色胺(5-HT)能神经元是否向臂旁核(PBN)投射. 方法: 荧光金(FG)逆行追踪结合5-HT免疫荧光组织化学染色的双标技术. 结果: 将FG注入PBN后,在PAG的尾段腹外侧区和DR观察到许多FG逆标神经元;5-HT阳性神经元密集地分布于DR,在PAG尾段的腹外侧区内,也能见到一些大型5-HT阳性神经元;PAG尾段腹外侧区和DR的部分FG逆标神经元呈5-HT 阳性. 结论: PAG和DR内的5-HT能神经元向PBN发出投射, 通过作用于PBN内的局部环路神经元或投射神经元,可能参与躯体和/或内脏伤害性信息通过PBN向前脑结构传递的调节.
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