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Influence of intracerebroventricular injection of urocortin Ⅲ on Fos expression in rat brain areas
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 11
- DOI:
- 10.3321/j.issn:1000-2790.2004.11.003
- Key Word:
- urocortinⅢ;脑室注射;Fos表达
Abstract： 目的:确定脑室注射UrocortinⅢ后被激活细胞群的分布,并判断这些细胞群的分布与其受体(促肾上腺皮质激素释放因子2型受体,CRF2R)的分布吻合程度.方法:应用免疫组织化学方法观察侧脑室注射UrocortinⅢ对大鼠不同脑区Fos表达的影响.结果:脑室给予UrocortinⅢ引起许多脑区Fos表达明显增多,包括隔外侧核、终纹床核、下丘脑室旁核、弓状核、杏仁中央核、臂旁核、孤束核和最后区.结论:侧脑室给予UrocortinⅢ激活了与味觉和摄食调控相关的细胞群以及与应激相关的细胞群,其分布与CRF2R的分布大部分重叠.
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