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Direction character of "critical sensitivity" phenomena in neural firing pacemaker
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 4
- DOI:
- 10.3321/j.issn:1000-2790.2004.04.002
- Key Word:
- 起步点;电生理学;分岔;电刺激
Abstract： 目的: 揭示神经放电起步点"临界敏感"现象的方向性特征. 方法: 在大鼠坐骨神经慢性压迫模型的放电起步点上,记录A类单纤维放电的峰峰间期(ISIs)序列. 当无钙条件下ISIs序列进入加周期分岔过程后,改变灌流液EGTA(钙离子螯合剂)浓度使其分别稳定于周期阶段、分岔前临界阶段及分岔后临界阶段,观察不同动力学阶段对电场刺激的反应. 结果: 在分岔前临界阶段,一定强度的兴奋性电场刺激可使放电频率显著增加,放电模式发生转化,而同样强度的抑制性电场刺激可使该阶段放电频率平缓减少,放电模式不变;在分岔后临界阶段,一定强度的抑制性电场刺激则使放电频率显著减少,放电模式发生转化,而同样强度的兴奋性电场刺激仅使该阶段放电频率平缓增加,放电模式不变. 结论: 神经放电起步点对电场刺激反应的"临界敏感"现象具有方向性特征.
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