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Effect of Salvia Miltiorrhiza Bge on myocardial pathological changes and hemorheology in spontaneously hypertensive rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 2
- DOI:
- 10.3321/j.issn:1000-2790.2004.02.002
- Key Word:
- 丹参;自发性高血压大鼠;心肌病变;血液流变学
Abstract： 目的: 研究长期应用丹参对自发性高血压大鼠(SHR)心肌病变及血液流变学的影响. 方法: 采用WKY大鼠及SHR大鼠,部分SHR大鼠给予丹参注射液ig 12 wk. 测量收缩压(SBP)、左心室质量指数(LVMI)和血液流变学指标,左心室组织切片用HE和VanGieson染色,全自动图像分析系统进行分析. 结果: 与WKY大鼠相比较,SHR组的左心室质量指数、TDM, CVF, PVCA和血液流变学指标明显升高,而用丹参治疗后,除收缩压外,各指标下降均有统计学意义(P<0.05). 结论: 丹参能预防和逆转左心室肥厚及心肌纤维化,其机制可能与改善血液流变学指标有关.
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