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Ultrastructural observing the effect of bioabsorbable material internal fixation on experimental fracture healing
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 1
- DOI:
- 10.3321/j.issn:1000-2790.2004.01.003
- Key Word:
- 生物相容性材料;内固定;骨折愈合;磷酸钙类;聚乳酸;超微结构
Abstract： 目的: 探讨自行研制的生物可吸收固定材料对骨折愈合的影响. 方法: 用生物可吸收固定材料(PDLLA/CMP)对20只兔(平均3.5 kg)股骨下端骨折进行髓内固定. 固定各2, 4, 8, 12和24 wk分别取骨折愈合区骨痂一组进行电镜下超微结构观察. 结果:①骨折第2周炎性反应期结束;②成纤维细胞出现在2～4 wk,成骨细胞出现在4 wk;③胶原纤维结构正常;④24 wk时骨细胞超微结构正常,无退变现象. 应用生物可吸收材料进行骨折内固定,骨折愈合细胞进程无明显变化;成骨过程活动正常;特别在较长时间固定后,骨细胞形态、结构无退变表现. 结论:用生物可吸收内固定物进行固定,其骨折愈合的超微结构表现与传统理论之间无明显差异,是一种有发展前途的可吸收内固定材料.
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