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Expression of tumor necrosis factor receptor 1 in deciduas from unexplained early spontaneous abortion
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 19
- DOI:
- 10.3321/j.issn:1000-2790.2003.19.003
- Key Word:
- 早期妊娠;流产;蜕膜;肿瘤坏死因子;受体
Abstract： 目的: 探讨肿瘤坏死因子受体Ⅰ(tumor necrosis factor receptor 1, TNFR1)在蜕膜中的表达及其与不明原因自然流产的关系. 方法:采用免疫组化方法,对31例妊娠6～10 wk不明原因早期自然流产患者(流产组)和30例同期妊娠的健康妇女(对照组)蜕膜组织中TNFR1的表达进行定位和半定量检测. 结果:流产组蜕膜腺体上皮、间质和血管内皮细胞TNFR1表达率分别为77.4%,93.5%和67.7%,对照组分别为96.7%,70.0%和23.3%. 腺体上皮细胞TNFR1表达率在2组之间无显著性差异(P=0.0529),流产组蜕膜间质及血管内皮细胞TNFR1表达率均高于对照组,均有显著性差异(P=0.0217, P=0.0008);蜕膜腺体上皮细胞TNFR1阳性表达强度低于对照组,有显著性差异(P<0.01),其间质TNFR1表达强度高于对照组,有显著性差异(P<0.01). 血管内皮细胞TNFR1阳性表达强度在2组之间无显著性差异(P>0.05). 结论:TNFR1在蜕膜间质及血管内皮细胞中表达水平的升高及其在腺体上皮细胞中表达水平的下降,可能与不明原因早期自然流产有关.
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