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Effects of nucleus accumbens core and shell lesions on the acquisition of drug-seeking behavior under morphine reinforcement
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 9
- DOI:
- No doi available
- Key Word:
- 伏隔核;觅药;毁损;吗啡
Abstract： 目的:分析伏隔核各亚区(外壳、核心)在吗啡觅药行为中的作用,研究定向毁损对大鼠成瘾行为的影响. 方法:雄性大鼠通过吗啡强化形成条件性地点偏好. 在反应稳定之后,使用直流电对大鼠行外壳或核心毁损(或空白对照). 待动物恢复后进行吗啡复燃,并测试其地点偏好数据. 结果:在7 d内,所有外壳毁损组和空白对照组动物均重新建立起了与毁损前相同的条件性地点偏好. 但是,伏隔核核心毁损却导致觅药行为的明显减退(P<0.05). 结论:在药物相关刺激条件下,伏隔核核心在吗啡觅药行为的建立方面起重要作用.
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