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Effect of hyperbaric oxygen on diffuse injured rats' brain histopathology
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 8
- DOI:
- 10.3321/j.issn:1000-2790.2003.08.004
- Key Word:
- 高压氧;脑损伤;脑;病理学;大鼠
Abstract： 目的: 研究高压氧(HBO)治疗对弥漫性脑损伤大鼠组织病理学的影响.方法:采用Marmarou介绍的落体打击装置制作弥漫性脑损伤大鼠模型,观察大鼠脑外伤后6 h,1 d,2 d,3 d,1 wk,2 wk,3 wk的病理学变化及0.2 MPa高压氧治疗对其影响,用免疫组化的方法观察损伤脑区NF表达情况,用干湿重法测量脑组织含水量.结果:大鼠脑外伤后顶叶皮层与海马出现不同程度神经元变性坏死;脑组织含水量较正常组高;视束处NF染色可见神经丝蛋白凝集成块,周围有空隙;给予高压氧治疗后坏死神经元较未治疗组明显减少,脑组织含水量明显降低(P<0.05).结论:大鼠脑外伤后出现广泛神经元变性坏死,大面积水肿,弥漫性轴突断裂,而高压氧治疗可明显减轻血管源性脑水肿,改善脑组织供氧,使变性坏死神经元数目减少.
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