You Position: Home > Paper
Significance of serum sICAM-1 in the clinical types of hepatitis B
( views:204, downloads:0 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 8
- DOI:
- 10.3321/j.issn:1000-2790.2003.08.002
- Key Word:
- sICAM-1;肝炎乙型,临床类型
Abstract： 目的: 观察血清sICAM-1水平在HBV感染者不同临床类型中的变化及其意义.方法 : 采用双抗体夹心ABC-ELISA法,对74例不同临床类型HBV感染者及10例正常对照者血清中可溶性细胞间粘附分子-1(sICAM-1)进行了定量测定. 结果 : 急性肝炎13例血清中sICAM-1含量(680±248) μg*L-1明显高于正常对照组(204±46) μg*L-1 (P<0.01); 46例慢性肝炎患者血清中sICAM-1含量(675±311) μg*L-1明显高于正常对照组(P<0.01);其中慢性肝炎轻度19例,sICAM-1含量(445±120) μg*L-1;慢性肝炎中度18例,sICAM-1含量为(634±182)μg*L-1,明显高于慢性轻度组(P<0.01);慢性肝炎重度9例,sICAM-1含量(931±280)μg*L-1,明显高于慢性轻度组(P<0.01).5例无症状携带者sICAM-1含量(212±72) μg*L-1,与正常对照组差别无显著性(P>0.05); 10例自然恢复组含量为(243±86) μg*L-1,与正常对照组差别无显著性.血清中sICAM-1含量与ALT含量呈明显正相关;而E抗原阳性组与E抗原阴性组差异无显著性.结论: 血清中sICAM-1水平测定可作为判别乙型肝炎临床类型的指标;sICAM-1含量与肝脏损伤程度成正比,sICAM-1含量与病毒复制状态无关.
- [1]张绪清,张瑞,顾长海,等.乙型肝炎肝内ICAM-1和HLA-A,B,C表达的研究[J].2001,(7).
- [2]X, Zhang,R, Zhang,C, Gu,etc.[The role of intercellular adhesion molecule-1/lymphocyte function-associated antigen-1 in the pathogenesis of viral hepatitis B].[J].2000,39(12).
- [3]M. Djokić,I. Bojić,M. Čolić,etc.The importance of hepatic expression of ICAM-1, HLA-DR, LFA-1 and HBcAg in chronic hepatitis B virus infection[J].1998,28(1).
- [4]Pugin J,Giostra E,Spahr L,etc.Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood.[J].2001,35(5).
- [5]Schmeisser H,Fuchsberger N,Kontsek P,etc.Significance of anti-interferon-alpha 2 and sICAM-1 activities in the sera of viral hepatitis B and C patients treated with human recombinant interferon-alpha 2[J].2001,45(5).