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Prediction of HLA-A2-restricted CTL epitope derived from tumor antigens associated with hepatocellular carcinoma
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 6
- DOI:
- 10.3321/j.issn:1000-2790.2003.06.004
- Key Word:
- 抗原,肿瘤;癌,肝细胞;HLA-A2抗原;T淋巴细胞,细胞毒性;表位
Abstract： 目的: 预测肝癌肿瘤抗原的HLA-A2限制性CTL表位. 方法: 选择与肝癌相关的肿瘤抗原MAGE-1,MAGE-3,MAGE-8,p53及AFP为研究目标,采用SYFPEITHI基序法远程预测系统和量化基序多项式法结合的预测方法进行HLA-A*0201限制性CTL表位预测. 结果: 共预测出与肝癌相关的肿瘤相关抗原的35个HLA-A2限制性CTL表位. 结论: 两种预测方法结果的一致性较好,所预测的35个肿瘤抗原HLA-A2限制性CTL表位经实验筛选、鉴定后,可望用于新型肝癌治疗性多肽疫苗的设计研究,为临床肝癌特异性治疗奠定基础.
- [1]K, Tahara,M, Mori,N, Sadanaga,etc.Expression of the MAGE gene family in human hepatocellular carcinoma.[J].1999,85(6).
- [2]M, Schirle,W, Keilholz,B, Weber,etc.Identification of tumor-associated MHC class I ligands by a novel T cell-independent approach.[J].2000,30(8).
- [3]Rammensee,H,Bachmann,J,Emmerich,NP,etc.SYFPEITHI: database for MHC ligands and peptide motifs.[J].1999,50(3/4).
- [4]Gulukota K.,Sette A.,Delisi C.,etc.Two Complementary Methods for Predicting Peptides Binding Major Histocompatibility Complex Molecules[J].1997,267(5).
- [5]M, Theobald,J, Biggs,J, Hernández,etc.Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes.[J].1997,185.
- [6]Andrew Koh,Wilson S.Meng,Charles M.Vollmer,etc.T cell responses to HLA-A& 0201-Restricted peptides derived from human #alpha# Fetoprotein[J].2001,166(8).
- [7]von den-Driesch-P,Brocker EB,Haendle I,etc.Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma.[J].1999,190(11).
- [8]Pierre van der Bruggen,Judy Bastin,Thomas Gajewski,etc.A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3[J].1994,24(12).
- [9]Read EJ,Avila N,Helman LJ,etc.Pilot trial of tumor-specific peptide vaccination and continuous infusion interleukin-2 in patients with recurrent Ewing sarcoma and alveolar rhabdomyosarcoma: an inter-institute NIH study.[J].2002,38(3).
- [10]Ichiro Kawashima,Stephen J Hudson,Van Tsai,etc.The Multi-epitope Approach for Immunotherapy for Cancer: Identification of Several CTL Epitopes from Various Tumor-Associated Antigens Expressed on Solid Epithelial Tumors[J].1998,59(1).