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Effects of Qidantongmai tablets on the equilibrium between NO and ET, 6-keto-PGF1αand TXB2 in plasma of dogs with myocardial ischemia reperfusion injury
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 5
- DOI:
- 10.3321/j.issn:1000-2790.2003.05.003
- Key Word:
- 缺血再灌注;缺血预处理;芪丹通脉片;血浆内皮素;一氧化氮;血栓素B2;6-酮-前列腺素
Abstract： 目的: 观察芪丹通脉片(Qidantongmai tablee, QDTMT)对心肌缺血再灌注损伤(MIRI)犬的血浆内皮素(ET)/一氧化氮(NO)平衡、血栓素B2(TXB2)/6-酮-前列腺素(6-keto-PGF1α)平衡的影响. 方法: 成年健康杂种犬24只,随机分为空白对照组(Control)、缺血预处理组(IP)、QDTMT低剂量组(QDTMTL)、QDTMT高剂量组(QDTMTH),均于同等条件下口服给药(或生理盐水)1 wk后,采用结扎犬冠状动脉左前降支的方法建立MIRI模型,分别测用药前(T1)、结扎后20 min (T2)、再灌注后10 min (T3),再灌注后30 min (T4)4个时间点血浆ET, NO, TXB2与6-keto-PGF1α的含量,分析NO/ET,6-keto-PGF1α/ TXB2的平衡关系. 结果: 与对照组比较,QDTMT组能降低血浆ET和TXB2水平,升高NO表达水平,提高6-keto-PGF1α的活性,升高NO/ET和6-keto-PGF1α/ TXB2比值(P<0.05, P<0.01),调节NO/ET及6-keto-PGF1α/ TXB2的平衡关系,QDTMTH及QDTMTL与IP比较无显著差异(P>0.05). 结论: QDTMT能起到与IP相似的保护作用. 其机制与降低血浆ET和TXB2水平,升高NO水平,提高6-keto-PGF1α活性,调节NO/ET和6-keto-PGF1α/ TXB2的平衡有关.
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