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Effects of Baobaole on gastrin and CCK in anorexia juvenile rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 5
- DOI:
- 10.3321/j.issn:1000-2790.2003.05.002
- Key Word:
- 厌食;胃泌素;CCK;宝宝乐口服液;儿宝颗粒;大鼠
Abstract： 目的: 研究运脾平肝复方宝宝乐口服液对小儿厌食症动物模型胃泌素及胆囊收缩素(cholecystokinin, CCK)的调节作用. 方法: 模拟小儿厌食症的主要病因制作幼龄厌食大鼠模型,用宝宝乐口服液治疗,用放免检测技术测定实验动物下丘脑、胃窦部及外周血胃泌素和CCK的含量,并与单纯运脾复方儿宝颗粒对照. 结果: 模型大鼠胃泌素含量胃窦部减少(P<0.05)、血清无明显变化、下丘脑未测出,下丘脑和血浆CCK-8浓度均明显增高(131.12±28.56 vs 91.08±18.68, P<0.05;486.95±113.32 vs 262. 15±95.09, P<0.01);宝宝乐和儿宝颗粒治疗组胃窦部胃泌素含量、下丘脑和血浆CCK-8浓度均恢复正常,宝宝乐治疗组下丘脑CCK-8浓度回降较儿宝颗粒明显(85.67±22.62 vs108.36±20.97, P<0.05). 结论: 宝宝乐能调节该模型中枢及外周胃泌素和CCK的分泌与释放.
- [1]杜永平,张月萍,胡三觉,等.运脾复方对幼龄厌食大鼠下丘脑外侧区和腹内侧区神经元自发放电的影响[J].2001,(2).
- [2]Yong Ping Du,Yue Ping Zhang,Shou Chuan Wang,etc.Function and regulation of cholecystokinin octapeptide, β-endorphin and gastrin in anorexic infantile rats treated with ErBao Granules[J].2001,(2).