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Experimental study on the effects of infrasound on structure of mouse ovary cell
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 4
- DOI:
- 10.3321/j.issn:1000-2790.2003.04.002
- Key Word:
- 次声;小鼠;卵巢/超微结构
Abstract： 目的: 研究次声暴露对小鼠卵巢细胞超微结构的影响.方法: 用BALB/c雌性小鼠随机分为3组.对照组置于次声舱内但无次声作用,实验组分为1,7和14 d组,分别暴露于8,16 Hz及90,130 dB声压场中,暴露结束当日处死,取卵巢固定.透射电子显微镜下观察卵巢细胞超微结构的变化情况. 结果: 1 d组中卵泡细胞可见不同程度的细胞变性、坏死,水肿,线粒体肿胀、空泡化,溶酶体增多,髓鞘样结构等一系列急性细胞损伤变化,尤以8 Hz, 130 dB损伤最严重.在7 d组中,卵巢细胞内可见大量类固醇和脂滴的结晶,卵母细胞微绒毛减少,卵黄颗粒增多.14 d组细胞出现卵泡细胞染色质的浓缩和边集. 结论: 次声暴露下可致卵泡细胞形态及分泌功能受损,使卵母细胞发育的内环境紊乱,发育异常.
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