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Clinical evaluation of myocardial protective effects of FDP enriched blood cardioplegia
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 20
- DOI:
- 10.3321/j.issn:1000-2790.2002.20.005
- Key Word:
- 果糖二磷酸盐类;氧合血;麻痹液;心肌保护
Abstract： 目的观察外源性1.6-二磷酸果糖(FDP)用于心脏停搏液,对心脏直视手术心肌缺血期间的保护作用. 方法将60例患者(其中瓣膜置换或成形32例,法乐氏四联症28例),随机分成St.ThomasⅡ号停搏液组(对照组)及FDP氧合血停搏液组(实验组). 观察两组不同停搏液灌注后患者心肌酶CPK-MB (hybrid muscle-brain CPK isoenzyme)的动态变化,术中心脏停搏情况,术后心脏复苏及血液动力学状况. 结果 FDP氧合血停搏液组血清CPK、MDA水平用量低于对照组. FDP加入停搏液能显著降低MDA含量,心脏超微结构保存较好. 术中心脏诱导停搏时间短,术后心脏复苏好,血液动力学稳定. 结论外源性FDP用于心脏停搏液,有明显的心肌保护效果.
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