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Study of pathomorph and ultrastructure for porcine valve decline in human body
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 20
- DOI:
- 10.3321/j.issn:1000-2790.2002.20.003
- Key Word:
- 移植异种;二尖瓣;猪
Abstract： 目的研究植入人体经戊二醛处理的生物猪瓣衰变后的形态和组织病理学变化特点. 方法取20枚再次二尖瓣置换患者手术时切除的衰变猪二尖瓣,观察其大体形态的变化和瓣叶的镜下超微结构及免疫组化的变化,同时和3枚未植入人体生物猪瓣比较. 结果 20枚生物瓣植入人体60～156(平均96.8) mo,切除后发现有16枚瓣叶撕裂,3枚瓣叶穿孔,1枚为感染性瓣膜炎,所有瓣膜均有不同程度的钙化;镜下见:胶原纤维透明变性,局灶性溶解,颗粒性物质增多和炎细胞侵润,纤维间粘多糖物质明显增加,尚见红细胞渗出和脂质体沉积. 免疫组化显示抗Ⅰ、Ⅲ型胶纤维单克隆抗体的表达较未移植猪瓣叶明显减弱. 结论戊二醛处理的猪瓣植入人体后,瓣叶胶原纤维退行性变性,撕裂与钙化是生物瓣衰败的病理基础,多糖类物质渗入和巨噬细胞吞噬作用加速病变过程.
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