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Dose-response effects of isoflurane preconditioning to induce ischemic tolerance in transient middle cerebral artery occlusion model in rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 15
- DOI:
- 10.3321/j.issn:1000-2790.2002.15.005
- Key Word:
- 异氟醚;预处理;脑缺血;剂量效应
Abstract： 目的研究异氟醚预处理脑保护作用的剂量效应关系. 方法 40只雄性SD大鼠,随机分为4组:对照组, Iso1, Iso2和Iso3组( n =10). 对照组大鼠每日吸4 L*min-1 (970 mL*L-1 O2) O2 1 h,连续5 d. Iso1, Iso2和Iso3组大鼠分别接受浓度为7.5, 15.0和22.5 mL*L-1的异氟醚预处理(异氟醚和4 L*min-1 O2),每日1 h,连续5 d. 最后1次处理结束24 h后,用右侧颈内动脉尼龙线线栓法制作大脑中动脉阻闭(middle cerebral artery occlusion, MCAO)模型. 异氟醚预处理效果根据再灌注24 h时的神经损害评分及脑梗死容积判定. 结果 Iso2和Iso3组大鼠神经功能障碍及脑梗死容积均与对照组及Iso1组相比差异显著( P <0.05). Iso3组大鼠神经功能障碍及脑梗死容积与Iso2组相比差异显著( P <0.05). 结论异氟醚预处理需达到一定浓度才能诱导脑缺血耐受,并存在一定的剂量效应关系.
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