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Effect of estrogen on interleukin-8 like immunoreactive substance in rat anterior pituitary
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 10
- DOI:
- 10.3321/j.issn:1000-2790.2002.10.005
- Key Word:
- 白细胞介素8;大鼠;垂体,前叶;雌二醇
Abstract： 目的研究孕鼠和大鼠性周期不同阶段以及大鼠体内雌激素水平变化对垂体前叶(Anterior pituitary, AP)内IL-8样免疫阳性物质表达的影响. 方法免疫组织化学ABC法. 结果 IL-8样免疫阳性物质在雌性大鼠性周期不同阶段有所差异,在动情期,垂体边缘IL-8样强染阳性细胞数明显增多;妊娠20 d大鼠的垂体前叶中央部分阳性细胞染色强度明显增加. 双侧卵巢摘除大鼠和正常雌性大鼠皮下注射25 μg*(kg*d)-1苯甲酸雌二醇2 wk后,也能观察到相同结果. 结论大鼠体内雌激素水平能影响垂体前叶内IL-8样免疫阳性物质的含量.
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