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Relationship between sensitivity to norepinephrine and firing pattern of substantia nigra compacta neurons
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 7
- DOI:
- 10.3321/j.issn:1000-2790.2002.07.002
- Key Word:
- 黑质致密部;自发放电;去甲肾上腺素;敏感性;非稳定周期轨道
Abstract： 目的研究黑质致密部(SNc)神经元的放电型式与其对去甲肾上腺素(NE)敏感性的关系,探讨"非周期敏感"现象的普遍性.方法在幼鼠的脑片胞外记录SNc神经元的自发放电.比较周期与非周期放电神经元对NE 反应的敏感性,对非周期放电神经元的放电进行非线性动力学分析.结果 NE对18个周期及12个非周期放电神经元呈现兴奋作用,对16个周期及12个非周期放电神经元呈现抑制作用.无论兴奋或抑制作用,非周期放电神经元对不同浓度NE的反应程度均比周期放电神经元大(P<0.01);NE 的兴奋及抑制作用可分别被酚妥拉明(20 μmol·L-1)及舒必利(1 μmol·L-1)阻断;在非周期放电神经元的放电序列中测出非稳定周期轨道.结论 SNc的非周期放电神经元比周期放电神经元对NE更敏感,这种敏感性可能与非周期放电的混沌特性有关.
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