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Endothelin-1 enhances norepinephrine-induced apoptosis in cardiac myocytes

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Author:
No author available
Journal Title:
JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
Issue:
1
DOI:
10.3321/j.issn:1000-2790.2002.01.003
Key Word:
心肌细胞;凋亡;内皮缩血管肽-1;去甲肾上腺素

Abstract: 目的探讨内皮素(ET-1)在去甲肾上腺素(NE)诱导的心肌细胞凋亡中的作用. 方法采用无血清培养新生大鼠心肌细胞模型,以免疫组化鉴定心肌细胞;以Hoechst 33258与PI双重荧光染色观察ET-1与NE单独或联合作用时心肌细胞凋亡率的变化. 结果①实验培养的新生大鼠心肌细胞的纯度达90%;②NE呈剂量依赖性诱导心肌细胞凋亡;ET-1对心肌细胞凋亡率无明显影响;ET-1与NE联合作用可显著增加心肌细胞的凋亡率. 结论内皮素-1可能促进去甲肾上腺素诱导的心肌细胞凋亡.

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