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Expression of EGFR and c-erbB-2 gene in human gliomas: An in situ hybridization study

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Author:
No author available
Journal Title:
JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
Issue:
23
DOI:
10.3321/j.issn:1000-2790.2001.23.002
Key Word:
表皮生长因子受体;c-erbB-2;基因表达;胶质瘤;原位杂交

Abstract: 目的探讨表皮生长因子受体(EGFR)和c-erbB-2基因表达与人脑胶质瘤发生发展的关系. 方法采用原位杂交方法检测52例人脑胶质瘤、 2株人脑胶质瘤细胞系及8例正常人脑组织中EGFR和c-erbB-2基因mRNA的表达. 结果 EGFR mRNA阳性率在高恶性度(Ⅲ~Ⅳ级)胶质瘤为79.2%,低恶性度(Ⅰ~Ⅱ级)胶质瘤为50.0%,二者差异显著(P<0.05); c-erbB-2 mRNA阳性率在高恶性度胶质瘤为83.3%,低恶性度胶质瘤为71.4%,二者无显著差别(P>0.05); EGFR和c-erbB-2 mRNA表达均随胶质瘤恶性程度增高而增强(P<0.01). EGFR和c-erbB-2 mRNA在2株人脑胶质瘤细胞系中均有表达,在8例正常人脑组织中均无表达. EGFR和c-erbB-2 mRNA表达结果密切相关(P<0.05). 结论 EGFR和c-erbB-2基因在人脑胶质瘤中普遍表达,且随胶质瘤恶性程度增高而表达增强,EGFR和c-erbB-2基因共表达在人脑胶质瘤发生发展过程中发挥重要作用.

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