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Effects of erythromycin on APD and main currents involved in action potentional in single guinea pig ventricular myocytes
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILTARY MEDICAL UNIVERSITY
- Issue:
- 21
- DOI:
- 10.3321/j.issn:1000-2790.2001.21.003
- Key Word:
- 红霉素;动作电位;IKr
Abstract： 目的通过观察红霉素对豚鼠单心室肌细胞动作电位时程(APD)及动作电位形成过程中主要跨膜离子电流的作用,探讨其诱发室性心律失常的电生理学机制. 方法采用膜片钳全细胞技术记录红霉素对ADP及主要电流的影响. 结果红霉素可使APD明显延长,并选择性地抑制了延迟整流钾电流(IK)中的快速激活成份IKr. 红霉素对心室肌细胞直接的电生理作用较弱, 只有在较高浓度时才会对单心室肌细胞APD及IKr产生抑制作用. 结论红霉素通过选择性抑制IKr而使APD延长,这可能是临床应用红霉素诱发室性心律失常的机制.
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