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Protective mechanism of verapamil on rat liver grafts under cold prese rvation and reperfusion

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Author:
No author available
Journal Title:
JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
Issue:
19
DOI:
10.3321/j.issn:1000-2790.2001.19.004
Key Word:
肝移植;维拉帕米;器官保存;再灌注损伤

Abstract: 目的在自制的器官保存液XJ-1液已取得较好结果的基础上,探讨维拉帕米对大鼠肝脏低温保存再灌注损伤的防护作用及其机制. 方法 XJ-1液与XJ-1+维拉帕米液保存大鼠肝脏 18 h后施行肝脏移植,检测术后血清转氨酶水平、肝组织钙离子及丙二醛含量等指标,观察大鼠术后1 wk存活率及移植肝脏的组织病理学改变. 结果 XJ-1+维液保存的大鼠肝脏移植后4 h,血清ALT,AST水平、肝组织钙离子含量、丙二醛含量均显著低于XJ-1液组(P<0.0 1, P<0 .05),光镜与电镜下肝组织形态学改变较XJ-1液组好,同时术后生存状况及1 wk存活率也优于XJ-1液(71% vs 57%). 结论维拉帕米能够减轻肝脏体外保存再灌注损伤,明显增强了XJ-1液对大鼠肝脏的保存效果,原因在于其阻滞钙通道的钙离子拮抗作用.

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