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Influence of homologuous antikeratin autoantibodies on serum IL-6 and IL-8 of rabbit model of contact dermatitis
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 15
- DOI:
- 10.3321/j.issn:1000-2790.2001.15.004
- Key Word:
- 抗角蛋白自身抗体;接触性皮炎;白细胞介素6;白细胞介素8
Abstract： 目的研究同种异体抗角蛋白自身抗体(AK auto Abs)对家兔接触性皮炎模型血清IL-6,IL-8的影响. 方法 24只家兔随机分为AK auto Abs组和对照组,每组12 只;AK auto Abs组im药物,剂量为5 mg*kg-1,1次*2 d-1,30 d;对照组动物以同样方法每次注射2 mL生理盐水. ELISA检测血清IL-6,IL-8水平变化. 结果 AK auto Abs组动物血清IL-6,IL-8的水平下降;对照组动物血清IL-6,IL-8的水平升高. 结论接触性皮炎可诱导IL-6,IL-8的产生;AK auto Abs则抑制IL-6,IL-8的产生.
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