Abstract： AIM　To explore the relationship between the variat ion of gastrointestin al hormones and the disorder of gastrointestinal motility in pixu. METHO DS　Pixu rat models (n=60) were treated by reserpine for seven days and fourteen days respectively. The somatostatin (SS) and cholecystokinin (CCK) levels in tissues and plasma of the rat models wa s measured by RIA. The normal group and the group prevented and treated by Sijun z i decoction (SIJD) were chosen for contrast. Gastrointestinal electrical-automa t ic motility were marked by chronically implanted electrodes and sensing element and compared between and after the treatment. RESULTS　In the ra t models of seve n days, as compared with controls, the plasma and hypothalamus levels of SS inc reased and periphery organization levels of SS reduced (P<0.01); both tissu es an d plasma had higher levels of CCK than those of controls (P<0.01); as compar ed wi th before the treatment, the rhythm and amplitude of stomach electrical-automat i c motility decreased (P<0.01); the rhythm of small bowl electrical slow wave decr eased while the amplitude increased; both rhythm and amplitude of small bowl aut omatic motility increased (P<0.01). In the rat models of fourteen days, the vari ation of SS in tissue and plasma was counted to the seven days'; as compared wit h controls CCK levels were higher in stomach and hypothalamus (P<0.01) and l ower in plasma and gut than those of the controls (P<0.01); as compared with bef ore the treatment, except the amplitude of stomach automatic motility, gastrointesti nal motility decreased (P<0.01). There had no significant disorder of SS, CC K an d gastrointestinal motility in the group prevented and treated with SIJD. CONCLU SION　There is relationship between the variation of gastrointestinal ho rmones a nd the disorder of gastrointestinal motility. They both vary with the developmen t of pixu and could be modulated by SIJD.