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Co-localization of GABAB receptor and serotonin in neurons of central endogenous pain control system of rats

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Author:
No author available
Journal Title:
JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
Issue:
10
DOI:
10.3321/j.issn:1000-2790.2001.10.002
Key Word:
受体,GABA-B;血清素;脑导水管;水管周灰质;中缝核;大鼠

Abstract: AIM To investigate the co-localization of GABA B receptor (GABABR) and serotonin (5-HT) in neurons of the midbrain periaqueductal gray (PAG), raphe nuclei and g igantocellular reticular nucleus pars α (GiA) of the rat. METHODS Im munofluorescence histochemical double- or triple-staining technique was used with specific anti bodies against GABABR and 5-HT or GABABR, 5-HT and GABA. RESULTS Densely stained GABA BR- and 5-HT-like immunoreactive double-labelled neuronal cell bodies were observed in the dorsal raphe nucleus (DR), median raphe nucleus (MnR), pontine raphe nucleus (PnR), nucleus raphe mag nus (NRM), nucleus raphe obscurus (ROb) and nucleus raphe pallidus (RPa). Additionally, GAB ABR/5-HT double-labelled neuronal cell bodies were also found in the PAG and GiA. GABA- like immunoreactive terminals were found to be in close appositions with GABABR/5- HT double-labelled neuronal cell bodies and proximal dendrites. CONCLUSION GABABR and 5-HT co-exist in majority of the serotonergic neurons in the PAG, raphe nuclei and GiA; GABA-ergic terminals form close contacts with GABABR/5-HT double-labeled neurons; GABA might regulate the activities of serotonergic neurons through GABABR by which to modulate the noxious information transmission.

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