Fos expression in brain of purified protein derivative of tuberculin immunized mice
- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MIL ITARY MEDICAL UNIVERSITY
- Issue:
- 4
- DOI:
- 10.3321/j.issn:1000-2790.2001.04.002
- Key Word:
- 结核菌素衍生蛋白;Fos;免疫应答
Abstract： AIM To further identify the response of brain areas to the immune stimulus. METHODS Using immunohistochemistry method, we observed the Fos expression in the brain of purified protein derivative of tuberculin (PPD) immunized mice at different time points. RESULTS At 3, 9, 14, 18, 21 d following the primary immunization and 7, 14 d following the second immunization, strong Fos immunostaining was observed in many brain areas such as the ventrolater-al medulla, central gray, hippocampus and neocortex. But the patterns at different time were not completely the same, especially in the cingulate cortex. Fos expression in the right side is stronger than that in the left side after second immunization with PPD. CONCLUSION It is suggested that many brain areas participate in the interaction of immune and central nervous system, and that brain asymmetry might be associated with the peripheral immune response.
- [1]S, Reichlin.Neuroendocrine-immune interactions.[J].1993,329(17).
- [2]D M, Nance,D, Rayson,R I, Carr.The effects of lesions in the lateral septal and hippocampal areas on the humoral immune response of adult female rats.[J].1987,1(4).
- [3]D. Saphier,O. Abramsky,G. Mor,etc.Multiunit electrical activity in conscious rats during an immune response[J].1987,1(1).
- [4]W H, Brooks,R J, Cross,T L, Roszman,etc.Neuroimmunomodulation: neural anatomical basis for impairment and facilitation.[J].1982,12(1).
- [5]K, Bizière,G, Renoux.Interactions between the neocortex and lymphocytes.[J].1986,9 Suppl 4.
- [6]K, Masek,P, Petrovicky,J, Seifert.An introduction to the possible role of central nervous system structures in neuroendocrine-immune systems interaction.[J].1992,14(3).
- [7]L. Wetmore,J. Greenjohnson,J.G. Gartner,etc.The Effects of Kainic Acid-Induced Lesions in the Lateral Septal Area on Cell-Mediated Immune Function[J].1994,8(4).
- [8]Heidi E.W. Day,Huda Akil.Differential Pattern of c-<i>fos</i>mRNA in Rat Brain following Central and Systemic Administration of lnterleukin-1-Beta: Implications for Mechanism of Action[J].1996,63(3).
- [9]G, Renoux,K, Bizière,M, Renoux,etc.A balanced brain asymmetry modulates T cell-mediated events.[J].1983,5(3).