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Effects of dopamine on experimentally form deprived myopia in rabbits

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Author:
No author available
Journal Title:
JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
Issue:
2
DOI:
10.3321/j.issn:1000-2790.2001.02.004
Key Word:
多巴胺;形觉剥夺;兔;近视;超声处理;病理学

Abstract: AIM To study effects of dopamine on form deprived myopia. [ WTHZ〗METHODS Fi fty-two of seven-day-old neonatal rabbits were divided into group A, B and C and monocularly deprived of pattern vision by suturation of right eyelids. I n group A (n=20), no drug was used, while rabbits in group B and C received a series of intravitreal injection of dopamine (n=16) or saline vehicle (n =16) with MD, respectively, the left eye were employed as control groups. Anterior chamb er depth (ACD), lenticular thickness (LT), vitreous chamber length (VCL) and axi al length (AL) of each eye were determined by means of A-scan ultrasonography on day 60, VCL/AL was calculated and pathologic changes were also observed. RESULTS VCL, AL and VCL/AL of deprived eyes in group A and C were ( 7.9±0.6) mm, (15.4±0.6) mm, 0.52±0.03; (7.3±0.5) mm, (15.1±0.7) mm, 0.49±0 .02; yet those of control eyes were (7.2±0.8) mm, (14.5±0.7) mm, 0.48±0.02; (6.8±0.4) mm, (14.6±0.6 ) mm, 0.46±0.02. VCL, AL and VCL/AL but not ACD and LT of deprived eyes showed a significant di fference in group A and C (P<0.001), yet these did not show any difference i n group B. Scleral collagen fibres of deprived eyes were markedly thinner in g roup A and C, but were less in group B. CONCLUSION Form depriva tion can induce axial elongation, longer vitreous chamber, higher VCL/AL and thinner scleral fib re do play a crucial role in the onset of myopia, while dopamine can partly bloc k these changes.

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