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Changes of concentration of cAMP and cGMP in pineal tissues and blood plasms of rat following exposure to electromagnetic pulse
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 11
- DOI:
- 10.3321/j.issn:1000-2790.2000.11.005
- Key Word:
- 电磁脉冲;松果体;cAMP;cGMP;放免分析
Abstract： 目的观察电磁脉冲(EMP)照射大鼠后,松果体和血浆中cAMP,cGMP浓度的变化,探讨EMP对大鼠昼夜节律的影响及机制. 方法采用放免分析法检测EMP照射大鼠后松果体及血浆中cAMP和cGMP的含量. 结果照射组大鼠松果体中cAMP,cGMP和cAMP/cGMP的数值及昼夜波动幅度均有明显降低(P<0.05),且位相发生移动;血浆中cAMP,cGMP位相也发生移动. 结论 EMP照射能影响大鼠松果体和血浆中第二信使cAMP,cGMP,从而干扰松果体细胞信号转导系统,进一步影响动物的昼夜节律.
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