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The expression and significance of TGFβ1 mRNA in excessive dermal scar of rabbit ears
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 4
- DOI:
- 10.3321/j.issn:1000-2790.2000.04.042
- Key Word:
- 原位杂交;TGFβ;增生性瘢痕
Abstract： 目的进一步探索建立兔耳增生性瘢痕动物模型的可能性. 方法在初步建立免耳增生性瘢痕模型基础上,用组织原位杂交方法,对兔耳增生块组织进行了TGFβ1 mRNA检测. 结果各组增生块组织TGFβ1 mRNA表达均较正常皮肤增多,但以注射TGFβ组早期表达最显著,各组随着时间推移逐渐减弱. 结论兔耳增生块组织TGFβ1 mRNA表达增加,与人增生性瘢痕结果相似.
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