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Effect of GAP-43 expression in spinal cord after irradiation on injured nerve of rat by diode laser
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 3
- DOI:
- 10.3321/j.issn:1000-2790.2000.03.004
- Key Word:
- 半导体激光;大鼠;脊髓;生长相关蛋白-43;神经损伤
Abstract： 目的研究15 mW半导体激光照射对大鼠损伤坐骨神经后脊髓中神经生长相关蛋白(growth associated protein, GAP-43)表达的影响. 方法 96只雄性S D大鼠制成坐骨神经损伤模型,15 mW半导体激光照射神经损伤部位,免疫组化方法观察脊髓内GAP-43表达的变化. 结果 1 wk内激光照射组和对照组无明显差异. 第2周和第4周时激光照射组脊髓内GAP-43表达明显高于对照组. 第8周时激光照射组较对照组脊髓内GAP-43表达稍低. 结论 15 mW半导体激光照射可引起损伤神经后大鼠脊髓中GAP-43表达的变化,有促进完成神经再生的作用.
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