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Establishment of unilateral dynamic pulmonary hypertension model in juvenil dogs
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 4
- DOI:
- 10.3321/j.issn:1000-2790.1999.04.017
- Key Word:
- 高血压;肺性;动物;模型
Abstract： 目的:探讨建立动力型肺动脉高压(PH)的方法及途径.方法:利用同种异体成年犬左锁骨下动脉,在幼犬降主动脉与左下肺动脉之间搭桥,造成降主动脉向左下肺动脉分流,建立幼犬动力型单侧PH模型.结果:该模型分流后3 mo左下肺动脉收缩压(11.13±1.51) kPa,[分流前为(1.36±0.32) kPa,P<0.001],左下肺动脉收缩压/体动脉收缩压力比值为0.67(分流前为0.13, P<0.001),肺动脉压显著增高,光镜及硫酸钡肺动脉灌注造影显示肺动脉内膜增生,中层肥厚.部分肺动脉阻闭.结论:该模型产生的血流动力学特征明显,全组成活率高,适于基础及临床研究用.
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