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Expression of protooncogene c-erbB-1 and c-erbB-2 in human gliomas
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 2
- DOI:
- 10.3321/j.issn:1000-2790.1999.02.004
- Key Word:
- 原癌基因;c-erbB-1;c-erbB-2;神经胶质瘤;基因表达
Abstract： 目的:探讨原癌基因c-erbB-1和c-erbB-2表达与人脑胶质瘤发生发展的关系. 方法:采用免疫组化SABC法检测52例人脑胶质瘤, 2株人脑胶质瘤细胞系及8例正常人脑组织中c-erbB-1和c-erbB-2蛋白的表达. 结果:c-erbB-1蛋白在Ⅰ～Ⅳ级胶质瘤组织中阳性率分别为50.0%,68.8%,81.8%和92.3%, 低恶性度(Ⅰ～Ⅱ级)胶质瘤(60.7%)和高恶性度(Ⅲ～Ⅳ级)胶质瘤(87.5%)间阳性率差异显著(P＜0.05);c-erbB-2蛋白在Ⅰ～Ⅳ级胶质瘤组织中阳性率分别为75.0%,87.5%,90.9%和92.3%,低恶性度胶质瘤(82.1%)和高恶性度胶质瘤(91.7%)间阳性率无显著差别(P＞0.05);c-erbB-1和c-erbB-2表达强度均随胶质瘤恶性程度增高而增强,在高恶性度和低恶性度胶质瘤间差异均极显著(P＜0.01);c-erbB-1和c-erbB-2在2株人脑胶质瘤细胞系中均有表达,在8例正常人脑组织中均无表达;c-erbB-1和c-erbB-2二者表达密切相关(P＜0.05). 结论:c-erbB-1和c-erbB-2在人脑胶质瘤中普遍表达,并随胶质瘤恶性程度增高而表达增强,c-erbB-1和c-erbB-2共表达可能是人脑胶质瘤发生发展过程中的重要事件.
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