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Application of calretinin in pathological diagnosis of Hirschsprung disease
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- Author:
- No author available
- Journal Title:
- Acta Academiae Medicinae Militaris Tertiae
- Issue:
- 19
- DOI:
- No doi available
- Key Word:
- 先天性巨结肠;钙视网膜蛋白;胆碱酯酶染色
Abstract： 目的 研究钙视网膜蛋白( calretinin,CR)免疫组织化学染色及胆碱酯酶染色(acetylcholinesterase staining,AchE)在先天性巨结肠(hirschsprung disease,HD)病理诊断中的作用对比,并探讨在直肠黏膜活检标本不足时CR的诊断作用.方法 采用回顾性研究的方法对比163例直肠黏膜活检CR免疫组织化学染色与AchE染色诊断HD准确性及敏感性.研究26例只含有1个黏膜下神经丛的直肠黏膜活检标本中,CR免疫组织化学染色辅助病理诊断的准确率.结果 在年龄＜3个月的病例组中,CR免疫组织化学染色敏感度显著高于AchE染色.CR免疫组织化学染色能够准确诊断21例只含有1个黏膜下神经丛的直肠黏膜活检HD病例.结论 CR免疫组织化学染色是一种优于AchE染色的直肠黏膜活检诊断HD的必要辅助方法.
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