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Hepatic arterial embolization with glycolic acid-ethylcellulose microspheres in treatment of hepatic tumor in rabbits
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- Author:
- No author available
- Journal Title:
- Academic Journal of Second Military Medical University
- Issue:
- 9
- DOI:
- 10.3724/SP.J.1008.2012.00954
- Key Word:
- 肝肿瘤;羟基乙酸;乙基纤维素;微球体;治疗性化学栓塞
Abstract： 目的 评价羟基乙酸乙基纤维素微球对兔VX2肝肿瘤的介入治疗作用.方法 将30只新西兰大白兔制作成VX2兔肝肿瘤模型,造模后13d行CT检查,计算荷瘤兔肿瘤体积,按肿瘤体积大小进行编号,采用随机数字表法分为A、B、C3组,每组10只.所有动物经右侧股动脉插管至肝动脉,行造影后向肿瘤供血动脉给药:A组注入羟基乙酸乙基纤维素微球1ml(0.023 g),B组注入碘油1ml,C组注入生理盐水1ml.记录实验动物介入治疗前后肝功能、肝脏肿瘤体积变化,观察各组治疗后肝肿瘤病理变化,从每组中随机选择5只观察生存期.结果 介入治疗前各组肝功能、肿瘤体积无统计学差异；介入治疗1周后,A、B组丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平均高于C组(P＜0.05)；CT测量显示A、B组肿瘤生长率低于C组(P＜0.01),且A组较B组更低(P＜0.01).H-E染色显示A组及B组肿瘤纤维组织包膜增厚,癌巢中央大片坏死,癌细胞排列松散,细胞核明显固缩,病理性核分裂减少；免疫组化染色显示A组的VEGF表达和PCNA增殖活性弱于B组.A组生存时间较B、C组延长(P＜0.05,P＜0.01).结论 羟基乙酸乙基纤维素微球肝动脉栓塞对VX2兔肝肿瘤有良好的治疗效果,使用安全.
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