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Spectratyping analysis of complementarity-determining region 3 of T-cell receptor beta chain variable region in peripheral blood mononuclear cells of patients with pemphigus vulgaris

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Author:
No author available
Journal Title:
ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY
Issue:
3
DOI:
10.3724/SP.J.1008.2009.00291
Key Word:
寻常型天疱疮;T淋巴细胞受体;互补决定区3;基因多态性

Abstract: 目的:探讨寻常型天疱疮(PV)患者外周血T细胞受体(TCR)互补决定区(CDR3)基因谱型变化,了解克隆扩增的T细胞与自身免疫性疾病的相互关系.方法:采用免疫扫描谱型分析技术,分析6例正常人外周血单个核细胞TCR β链可变区(BV) CDR3谱型分布特征以及6例PV患者CDR3谱型变化情况.结果:6例正常人TCR BV CDR3谱型均符合正态分布,6例PV患者TCR BV CDR3谱型均出现多态性降低,BV亚家族单/寡克隆增生.结论:PV患者外周血TCR可变区β链CDR3谱型异常可能与PV发病有关.

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