Expression and significance of breast cancer suscepterbility gene 1 in leukemia

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Author:
MAO Chun-xia(Department of Hematology, Huangdao Branch, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266000, China)
LIN Feng-ru()
ZHANG Zhi-min()
Journal Title:
Journal of Leukemia & Lymphoma
Issue:
Volume 21, Issue 10, 2012
DOI:
10.3760/cma.j.issn.1009-9921.2012.10.004
Key Word:
Breast cancer suscepterbility gene 1;Leukemia;Expression

Abstract: Objective To investigate the expression and significance of breast cancer suscepterbility gene 1 (BRCA1) in leukemia.Methods Fluorescent quantitative reverse transcription-polymerase PCR was used to investigate the expression of BRCA1 in 18 patients with ALL-L2 (13 denovo ALL patients,5 relapsed ALL patients),20 patients with CML-CP and 15 normal controls.Results The mRNA expression of BRCA1 in denovo patients with ALL was lower than that in normal control,with statistical significance (P < 0.05).The mRNA level of BRCA1 in ALL patients in CR was higher compared with before to cure, with statistical significance (P < 0.05),but lower than that in normal control,without statistical significance(P > 0.05).The mRNA expression of BRCA1 in patients with relapsed ALL was lower than that in normal control with statistical significance (P < 0.05), and lower than that in denovo patients with ALL, without statistical significance (P > 0.05).The mRNA level of BRCA1 showed no difference in CML-CP patients compared with normal control (P > 0.05). Conclusion The different expression of BRCA1 in leukemia indicates that he has closely relationship with the prognosis of leukemia and guides the clinical diagnosis and treatment.

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