Clinical observation of modified CHOP regimen in the initial treatment of non-Hodgkin's lymphoma patients with low Karnofsky score

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Author:
LI Tao(Department of Chemotherapy, Gaozhou People's Hospital of Guangdong Province, Gaozhou 525200, China)
WU Xiang-cheng(Department of Chemotherapy, Gaozhou People's Hospital of Guangdong Province, Gaozhou 525200, China)
LING Hua-huang(Department of Chemotherapy, Gaozhou People's Hospital of Guangdong Province, Gaozhou 525200, China)
HUANG Xi-mei(Department of Chemotherapy, Gaozhou People's Hospital of Guangdong Province, Gaozhou 525200, China)
WU Fei-chang(Department of Chemotherapy, Gaozhou People's Hospital of Guangdong Province, Gaozhou 525200, China)
SU Bing-guang(Department of Chemotherapy, Gaozhou People's Hospital of Guangdong Province, Gaozhou 525200, China)
Journal Title:
Journal of Leukemia & Lymphoma
Issue:
Volume 21, Issue 08, 2012
DOI:
10.3760/cma.j.issn.1009-9921.2012.08.008
Key Word:
Lymphoma,non-Hodgkin's; Antineoplastic combined chemotherapy protocods; Karnofsky

Abstract: Objective To observe the effecacy of modified CHOP regimen in the initial treatment of non-Hodgkin' slymphoma (NHL) patients with low Karnofsky score.Methods Twenty initial treatment NHI.patients with low Karnofsky score were randomly allocated into treatment group and control group,respectively treated with modified and standard CHOP regimen.Results Of 13 cases in treatment group,12 pacients'Karnofsky score were over 60.1 was still below 60,overall response (OR) rate was 92.3 % (12/13).while in control group,3 patients' Karnofsky score were over 60,4 were still below 60.OR rate was 100 % (7/7),rate of marrow toxicity was 57.1 % (4/7).There were no significantly difference for OR rates (P =0.4515),but for improving Karnofsky score there were significantly difference (P =0.0149).Conclusion Modified CHOP regimen can improve Karnofsky score of NHL patients with low Karnofsky score,benefical for further treatment and reducing hospitalization cost.

  • [1]McKelvey EM,Gottlieb JA,Wilson HE,et al.Hydroxyldaunomycin (Adriamycin) combination chemotherapy in malignant lymphoma.Cancer,1976,38:1484-1493.
  • [2]Messori A,Vaiain M,Trippol S,et al.Survival in patients with intermediate or high grade non-Hlodgkin’s lymphoma:meta-analysis of randomized studies comparing third generation regimens with CHOP.Cancer,2001,84:303-307.
  • [3]张明智,姚志华,耿丽,等.改良CHOP方案治疗老年侵袭性非霍奇金淋巴瘤临床观察.肿瘤研究与临床,2006,19:209-210.
  • [4]顾志峰,徐瑞容,吴芳颐,等.改良CHOP方案治疗老年非霍奇金淋巴瘤68例临床分析.南通医学院学报,2002,22:198-200.
  • [5]罗盛,胡旭东,沈志坚,等.ESHAP方案治疗复发或难治性侵袭性非霍奇金淋巴瘤.肿瘤研究与临床,2007,19:763-765.
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