You Position: Home > Paper

GDP regimen as salvage treatment for relapsed refractory non-Hodgkin's lymphoma

( views:345, downloads:100 )
Author:
No author available
Journal Title:
Journal of Leukemia & Lymphoma
Issue:
8
DOI:
10.3760/cma.j.issn.1009-9921.2012.08.007
Key Word:
淋巴瘤,非霍奇金;抗肿瘤联合化疗方案;复发;难治;Lymphoma,non-Hodgkin;Antineoplastic combined chemotherapy protocols;Recurrence;Refractory

Abstract: Objective To study the effect and safety of GDP regimens (gemcitabine,cisplatin,dexamethasone) as salvage chemotherapy in relapsed refractory non-Hodgkin’s lymphoma (NHL).Methods Clinical response and adverse effects of 34 NHL patients treated by GDP regimens were analyzed retrospectively.Results The overall response rate (ORR) was 52.9 % (18/34),there was no statistic difference between ORR in relapsed NHL [72.7 % (8/11)] and that in refractory ones [43.5 % (10/23)](P =0.11).The ORR for B-NHL was 64.0 % (16/25),while for T-NHL was 22.2 % (2/9),there was no statistic difference between them (P =0.052).The ORR for low risks groups was 66.7 % (6/9),while it for intermediate-risk and high-risk ones were 55.6 % (10/18) and 28.6 % (2/7),respectively,the effect of GDP regimens for low-risk group was better for high-risk ones,but there was no statistic difference (P =0.349).The incedience of Ⅲ-Ⅳ granulopenia reduced was 23.5 % (8/34) and there were no Ⅲ-Ⅳ gastrointestinal adverse reactions or liver and kidney toxicity.Conclusion GDP regimens were efficient and less toxic as second-line salvage chemotherapy.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn