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Analysis of prognostic factors of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

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Author:
No author available
Journal Title:
Journal of Leukemia & Lymphoma
Issue:
8
DOI:
10.3760/cma.j.issn.1009-9921.2012.08.003
Key Word:
淋巴瘤,黏膜相关淋巴样组织;原位杂交,荧光;预后;Lymphoma,mucosa-associated lymphoid tissue;In situ hybridization,fluorescence;Prognosis

Abstract: Objective To study the clinicopathologic features and explore the potential prognostic factors of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma).Methods 86 patients diagnosed with MALT lymphoma were retrieved and divided into 2 subgroups according to the location of tumor,namely gastric (32 cases) and non-gastric (54 cases) subgroup.Histological characteristics were reassessed on hematoxylin-eosin staining slides,and immunophenotypic features were determined by immunohistochemical staining.Interphase fluorescence in-situ hybridization (FISH) was carried out to detect the cytogenetic abnormalities.Results There were no significant difference of clinical behavior,histology,and immunophenotype between gastric and non-gastric subgroups.In addition,FISH detected t(14;18) in 9 % (4/45) and t(11;18) in 12 % cases (6/50) respectively.Among the 20 cases treated with H pylori (HP) eradication,a significantly lower remission rate was observed in cases with bcl-10 (20 %) nuclear expression or those harboring t(11;18) (33 %) compared with those in the negative group (73 %,91%)(x2 =3.842 and 4.639,P =0.035 and 0.031,respectively).For the 35 non-gastric patients with follow-up data,males (35 %) and patients older than 60 yrs (25 %) tended to have a lower remission rate as compared to females (60 %) and those younger than 60 yrs (63 %) (x2 =3.905 and 7.373,P =0.048 and 0.007,respectively).Moreover,progression-free survival rate was significantly lower in patients with higher stage (ⅢⅣ) (25 %) and without t(14;18) (50 %) than that in patients with stage Ⅰ-Ⅱ (52 %) and with t(14;18)(75 %).The differences had statistical significance (x2 =4.207 and 4.363,P =0.040 and 0.037,respectively).Conclusion MALT lymphoma in general is an indolent B-cell non-Hodgkin’ s lymphoma which more frequently occurs in the elderly people.Differences in the response to treatment or the prognosis are observed between gastric and non-gastric MALT lymphoma patients.

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