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Clinical significance of MRD detection in ALL-B of children by FCM

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Author:
No author available
Journal Title:
Journal of Leukemia & Lymphoma
Issue:
7
DOI:
10.3760/cma.j.issn.1009-9921.2012.07.012
Key Word:
白血病,双表型,急性;流式细胞术;复发;儿童;微小残留病;Leukemia,biphenotypic,acute;Flow cytometry;Recurrence;Children;Minimal residual disease

Abstract: Objective To evaluate the clinical significance of minimal residual disease (MRD)detecion in ALL-B of children by flow cytometric (FCM).Methods 52 cases of children with ALL-B were performed bone marrow MRD by FCM analisis after induction therapy,3 moths therapy,and 6 moths therapy.After that,MRD detection was performed every 6 months. According to disease risks, three group were categorized,standard risk (SR),imidiete risk (IR) and high risk(HR).Results After 6 months,SR groups MRD positive cases were 4/21(19 %),IR groups MRD position cases were 8/23 (35 %),HR groups MRD position cases were 5/8 (63 %).9 cases relapsed in all 52 patients.There were significant differrence in replased rate between the positive and negtive MRD (P<0.001). Conclution The dynamic detection of MRD by FCM can be used to evaluate the therapeutic effect and prognosis of children with ALL-B. It is also useful in adjusting treatment strategy and for following up in children with ALL.

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