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Differential expression of genes in dendritic cell induced by human alloantigens and cytomegalovirus antigen

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Author:
No author available
Journal Title:
Journal of Leukemia & Lymphoma
Issue:
6
DOI:
10.3760/cma.j.issn.1009-9921.2012.06.003
Key Word:
树突状细胞;同种异体抗原;巨细胞病毒抗原;急性移植物抗宿主病;寡核苷酸序列分析;Dendritic cells;Alloantigens;Cytomegalovirus antigen;Acute graft-versus-host disease;Oligonucleotide array sequence analysis

Abstract: [Objective]To investigate differential gene expression in dendritic cell(DC) in response to human alloantigen and cytomegalovirus protein,and search target genes which can prevent graft rejection and eytomegalovirus (CMV) infection.[Methods]Genome-wide microarray analysis was performed to test gene expression in DC in response to human alloantigen and cytomegalovirus protein 3A(CMV3A).[Results]The Results showed that the difference of gene expression of DC induced by CMV3A and alloantigen was significant.The genes with differential expression included antigen processing and presentation,toll-like receptor signaling pathway and cell movement/migration, cytokine-cytokine receptor interaction and metabolism of xenobiotics by cytochrome p450,and several heat shock protein(HSP) family members including HSPA5,HSPA8,HSPA9B and HSP90AB1,in DC induced hy alloantigen were higher expression than that by CMV3A.[Conclusion]This study found several genes including heat shock protein family in DC induced by alloantigen were higher expression than that by CMV3A,these genes might play a valuable role in preventing graft rejection and CMV infection.

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