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Cell death and malignant lymphoproliferative disorders regulated by bcl-2 family

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Author:
No author available
Journal Title:
Journal of Leukemia & Lymphoma
Issue:
4
DOI:
10.3760/cma.j.issn.1009-9921.2012.04.021
Key Word:
bcl-2;细胞;淋巴瘤;淋巴组织增殖性疾病;bcl-2;Cells;Lymphma;Lymphoproliferative disorders

Abstract: As important regulators of apoptosis,bcl-2-family proteins regulate all major types of cell death,including apoptosis,necrosis,and autophagy.It's known that impaired apoptosis is a critical step in tumor development.Overexpression of antiapoptotic proteins of bcl-2 family is associated with the development and prognoses of malignant lymphoproliferative disorders.

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