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Choice of viral vector for gene therapy on hematological malignancies
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- Author:
- No author available
- Journal Title:
- Journal of Leukemia & Lymphoma
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-9921.2012.03.020
- Key Word:
- 血液肿瘤;基因;反转录因子;Hematologic neoplasms;Genes;Retroelements
Abstract： Gene therapy,a target therapy with biological markers,can be used as an alternative choice for refractory and relapsed hematologic malignancies. Reasonable choice of viral vectors is the key to treatment.This article will be reviewed on five aspects,which are the characteristics of the carrier,gene insertion mutation,the immune barrier,improvement the targeting of the vector and maintenance and expression of the transgene.
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