A20 and TNF genes aberration in ocular adnexal MALT lymphomas
- Author:
- No author available
- Journal Title:
- Journal of Leukemia & Lymphoma
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-9921.2012.03.004
- Key Word:
- 淋巴瘤,B细胞,边缘区;眼肿瘤;基因,A20;基因,TNF;原位杂交荧光;Lymphoma,B-cell,marginal zone;Eye neoplasms;Genes,A20;Genes,TNF;In situ hybridization,fluorescence
Abstract： Objective To investigate the copy number changes of A20 and TNF genes,and determine the contribution of the two genes in the development of ocular adnexal MALT lymphoma.Methods Forty-one cases of archive paraffin-embedded ocular adnexal MALT lymphoma tissues were detected by interphase fluorescence in situ hybridization (FISH) using the commercial chromosome 6 centromere probe (CEP6),and house-made site-specific probe of A20 and TNF. Results Of the 41 ocular adnexal MALT lymphoma cases,loss of heterozygosity (LOH)in A20 locus was detected in 2 cases (4.88 ％).TNF extra copies were found in 5 cases (12.20 ％),of which three cases simultaneously had extra CEP6 signals.No A20 deletion were found coexistence with TNF extra copies in any case.Conclusion A20 gene deletion is present in the small part of ocular adnexal MALT lymphoma, and might contribute to the development of Chinese ocular adnexal MALT lymphoma.A20 deletion is not associated with extra copies of TNF locus.
- [1]吕蓓蓓,周春菊,杨文萍,等.儿童侵袭性成熟B细胞淋巴瘤的临床病理学及分子遗传学特点[J].2011,(3).
- [2]解婧,王杰军.锌指蛋白A20与恶性肿瘤相关性研究的进展[J].2010,(1).
- [3]游启生,李彬,周小鸽,等.112例眼附属器淋巴增生性病变临床组织病理学初步分析[J].2005,(10).
- [4]Bharat B, Aggarwal.Signalling pathways of the TNF superfamily: a double-edged sword.[J].2003,3(9).
- [5]C. Ferran,D.M. Stroka,A.Z. Badrichani,etc.Adenovirus-mediated gene transfer of A20 renders endothelial cells resistant to activation: A means of evaluating the role of endothelial cell activation in xenograft rejection[J].1997,29(1-2).
- [6]Ferran C,Stroka DM,Palmetshofer A,etc.A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism.[J].1996,271(30).
- [7]Nakamura N,Abe M,Kuze T,etc.Immunoglobulin heavy chain gene analysis of ocular adnexal extranodal marginal zone B-cell lymphoma.[J].2001,42(11).
- [8]Kazuki, Tanimoto,Naohiro, Sekiguchi,Yukiko, Yokota,etc.Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma.[J].2006,6.
- [9]Rajashankar K,Lam AY,Lamothe B,etc.Molecular basis for the unique deubiquitinating activity of the NF-kappa B inhibitor A20[J].2008,376(2).
- [10]Arevalo JF,Lowder CY,Muci Mendoza R.Ocular manifestations of systemic lupus erythematosus.[J].2002,13(6).
- [11]Meunier J,Decaudin D,Plancher C,etc.Ophthalmologic and intraocular non-Hodgkin's lymphoma: a large single centre study of initial characteristics, natural history, and prognostic factors.[J].2004,22(4).
- [12]Beyaert R,Chen ZJJ,Sun LJ,etc.T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappa B inhibitor A20[J].2008,9(3).
- [13]Honma K,Ko YH,Seto M,etc.TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma.[J].2008,47(1).
- [14]Liu H,Zhang D,Zhou X,etc.Ocular adnexal mucosa-associated lymphoid tissue lymphoma in Northern China: high frequency of numerical chromosomal changes and no evidence of an association with Chlamydia psittaci.[J].2010,51(11).
- [15]Huang Y,Ichimura,Chanudet E.A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma.[J].2010,24(2).
- [16]Ley SC,Verhelst K,Carpentier I,etc.Expression, biological activities and mechanisms of action of A20 (TNFAIP3).[J].2010,80(12).
- [17]A W, Opipari,M S, Boguski,V M, Dixit.The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.[J].1990,265.
- [18]Honma K,Tagawa H,Ko YH,etc.Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma: Comparison with pulmonary and nodal marginal zone B cell lymphoma.[J].2007,46(8).
- [19]Joyce DA,Lo SZ,Steer JH.TNF-alpha renders macrophages resistant to a range of cancer chemotherapeutic agents through NF-kappaB-mediated antagonism of apoptosis signalling.[J].2011,307(1).
- [20]Cerri M,Rossi D,Gaidano G,etc.The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.[J].2009,113(20).
- [21]左云龙,匡凤梧,吴丽娟.A20的泛素修饰抑制NF-κB活性[J].2007,032 (5).