Study of cytogenetic characteristics on myelodysplastic syndrome and acute myeloid leukemia

( views:108, downloads:0 )
Author:
WANG Li-na(Department of Hematology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China)
YE Fang(Department of Hematology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China)
LI Guo-xia(Department of Hematology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China)
JIA Ning(Department of Hematology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China)
HE Yu-mei(Department of Hematology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China)
Journal Title:
Journal of Leukemia & Lymphoma
Issue:
Volume 21, Issue 02, 2012
DOI:
10.3760/cma.j.issn.1009-9921.2012.02.012
Key Word:
Myelodysplastic syndromes;Leukemia,myeloid,acute;Leukemia,monocytic,acute;Cytogenetics

Abstract: Objective To evaluate the cytogenetic characteristics of the patients with acute myelomonocytic leukemia (AML-M4), acute monocytic leukemia (AML-M5) and myelodysplastic syndrome (MDS).Methods Chromosomes of bone marrow cells were prepared by short-term culture.Karyotype analysis was performed in 100 AML-M4,46 AML-M5 and 115 MDS by R-banding technique.Results 26 % (26/100) AML-M4 had clonal cytogenetic abnormalities which mainly include +8,t(8;21) and -7.26 % (12/46) AML-M5 had clonal cytogenetic abnormalities which mainly include +11. 39 % (45/115) had clonal cytogenetic abnormalities which mainly include +8, Hypodiploid and -7. Conclusion Cytogenetic detection is very important for the diagnosis of myelodysplastic syndrome and acute myelocytic leukemia.

  • [1]张之南.血液病诊断及疗效标准.2版.北京:科技出版社,1998:168-267.
  • [2]周惠芬,李建勇,潘金兰,等.急性粒-单核细胞白血病的细胞遗传学异常研究.中国癌症杂志,2006,16:733-736.
  • [3]Paulsson K, Fioretos T, Strombeck B, et al. Trisomy 8 as the sole chromosomal aberration in 8 myelocytic malignancies:a multicolor and locus-specific fluorescence in situ hybridization study. Cancer Genet Cytogenet,2003,140:66-69.
  • [4]Virtaneva K, Wright FA, Tanner SM, et al. Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics. Proc Natl Acad Sci U S A,2001,98:1124-1129.
  • [5]Tian L,Liu LB,Wang XB,et al.Impact of trisomy 8 on cytobiological and clinical features of acute myelomonocytic and monocytic leukemia.Zhongguo Shiyan Xueyexue Zazhi,2005,13:364-368.
  • [6]赖悦云,邱镜滢,江滨,等.t(8;21)急性髓性白血病特征和预后分析.中国实验血液学杂志,2005,13:733-740.
  • [7]王怡,牧启田,陆滢,等.累及单核细胞系急性白血病50例核型分析.实用医学杂志,2009,25:947-948.
  • [8]李建勇,潘金兰,吴亚芳,等.间期荧光原位杂交技术检测急性粒-单核细胞白血病inv(16).中华血液学杂志,2002,23:30-32.
  • [9]Udayakumar AM,Pathare AV,Muralitharan S,et al.Trisomy 21 as a sole acquired abnormality in an adult Omani patient with CD7-and CD9-positive acute myeloid leukemia.Arch Med Res,2007,38:797-802.
  • [10]贾治林,荆源,林樉,等.急性单核细胞白血病60例核型和预后分析.中国实用内科学杂志,2010,30:558-559.
  • [11]樊伟,刘晓丽,杜庆锋,等.急性髓细胞白血病M4/M5亚型的临床和遗传学研究.山东医药,2007,47:4-6.
  • [12]Greenberg P,COX C,Lebeau MM,et al.International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood, 1997,89:2079-2088.
  • [13]Nowell PC. Chromosome abnormalities in myelodysplastic syndrome.Seroin Oncol,1992,19:25-33.
  • [14]薛永权.染色体异常在白血病和骨髓异常增生综合征发病中的作用.国外医学输血及血液学分册,2004,27:520-523.
  • [15]李辚,刘旭平,聂玲,等.原发性骨髓增生异常综合征染色体核型异常特征及其预后意义的研究.中华血液学杂志,2009,30:217-221.
  • [16]冯宝章,雷健玲,刘焕勋,等.骨髓增生异常综合征染色体异常与白血病发展.白血病·淋巴瘤,2004,13:330-334.
  • [17]Haase D,Germing U,Schanz J,et al.New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes:evidence from a core dataset of 2124 patients. Blood, 2007, 110:4385-4395.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn