Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly: 2 cases report and review of the literature

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Author:
LIU Yan(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
DONG Fei(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
ZHAO Wei(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
TIAN Lei(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
WAN Wei(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
KE Xiao-yan(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
WANG Jing(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
GAO Zi-fen()
HE Yao-xin()
WANG Ji-jun(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
JING Hong-mei(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
HU Kai(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
CHEN Yu-ping(Department of Hematology, Peking University Third Hospital, Beijing 100191, China)
Journal Title:
Journal of Leukemia & Lymphoma
Issue:
Volume 20, Issue 10, 2011
DOI:
10.3760/cma.j.issn.1009-9921.2011.10.008
Key Word:
Lymphoma, large-cell, diffuse;Herpesvius 4, human;Splenomegaly;Respiratory insufficiency

Abstract: Objective To study the Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) of the elderly and explore its clinical characteristics. Methods The clinical manifestation,laboratory examination and treatment of two cases of EBV positive DLBCL of elderly were lescribed.Results EBV positive DLBCL of elderly onset was often between 70-79 years,usually presented with lymphadenopathy and may be extranodal,may present with massive splenomegaly,secondary immune hemolytic anemia and often had B symptom.Pathologically,this disease was characterized by a proliferation of atypical large B cells with rich reactive cells,especially T cell.Conclusion Immunohistochemically,the tumor cells of EBV positive DLBCL of elderly present with CD20 or CD79a,EBV-encoded small RNA (EBER) positive.This disease has aggressive clinical course,a poor response to standard treatment.Rituximab may be effective in a short periods,but the long effect is limited.Overall survival is short.The cause of death is mainly respiratory failure due to factor infection.

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