State of unrelated cord blood transplantation

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Author:
ZHENG Chang-cheng(Department of Hematology, Anhui Provincial Hospital, Hefei 230001, China)
SUN Zi-min(Department of Hematology, Anhui Provincial Hospital, Hefei 230001, China)
Journal Title:
Journal of Leukemia & Lymphoma
Issue:
Volume 20, Issue 09, 2011
DOI:
10.3760/cma.j.issn.1009-9921.2011.09.003
Key Word:
Hematopoietic stem cell transplantation;Cord blood stem cell transplantation;Unrelated

Abstract: Cord blood is the main source of stem cell outside of bone marrow and peripheral blood, and cord blood transplantation, especially unrelated cord blood transplantation (UCBT) has been widely used. The major challenges in UCBT are delayed engraftment and graft rejection. Many approaches have been investigated to enhance collection of HSC and HPC in cord blood units, sinduding use of double unit UCBT, adopt reduced intensity conditioning (RIC) approach, amplification of cord blood cells in vivo or ex vivo, and co-infusion with a haploidentical T cell depleted graft or mesenchymal stem cells (MSC), or injecting cord blood cells directly into the bone marrow. Those approaches may greatly increase the clinical use of cord blood cells for transplantation.

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