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Progression of targeted therapy of multiple myeloma bone disease

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Author:
No author available
Journal Title:
JOURNAL OF LEUKEMIA & LYMPHOMA
Issue:
6
DOI:
10.3760/cma.j.issn.1009-9921.2011.06.015
Key Word:
多发性骨髓瘤;骨病医学;细胞因子类;靶向治疗;Multiple myeloma;Osteopathic medicine;Cytokines;Targeted therapy

Abstract: Multiple myeloma (MM) is a hematological malignancy. Osteolytic lesion is the commonest complication in patients with MM. Skeletal-related events severely affect the survival quantity and prognosis. Current therapeutic approach for the treatment of myeloma bone disease (MBD) is based on the use of bisphosphonates. AS the recent advance in the pathogenesis and therapeutics of MBD,more factors related to this disease are found. In this article important factors related to the pathogenes of MBD and the cytokine targeted therapies are reviewed.

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